Two sample MR report

Telomere_length against aparc-Desikan rh area pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0499134	0.1144100	0.6670947
Weighted median	23	-0.0331752	0.0626806	0.5966153
Inverse variance weighted	23	0.0168599	0.0437837	0.7001840
Simple mode	23	-0.0980374	0.1082482	0.3749218
Weighted mode	23	-0.0831476	0.1237146	0.5085223

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.81996	21	0.1453317
Inverse variance weighted	27.95046	22	0.1773287

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020295	0.0064663	0.756723

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008526	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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