Two sample MR report

Telomere_length against aparc-Desikan rh area parstriangularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0009755	0.1420438	0.9945853
Weighted median	23	-0.0252094	0.0584488	0.6662452
Inverse variance weighted	23	-0.0144473	0.0542492	0.7899980
Simple mode	23	0.0828392	0.1277972	0.5235588
Weighted mode	23	-0.0222984	0.0729198	0.7626367

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.88027	21	0.0032559
Inverse variance weighted	42.90868	22	0.0048427

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000947	0.008028	0.9072227

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013044	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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