Two sample MR report

Telomere_length against aparc-Desikan rh area parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1141971	0.1267377	0.3777797
Weighted median	23	0.0774448	0.0663167	0.2428868
Inverse variance weighted	23	0.0186889	0.0491534	0.7037856
Simple mode	23	0.0597313	0.1238525	0.6343720
Weighted mode	23	0.0857488	0.0843121	0.3201890

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.13455	21	0.0350553
Inverse variance weighted	35.22401	22	0.0367067

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0058643	0.007163	0.4221592

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010744	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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