Two sample MR report

Telomere_length against aparc-Desikan rh area parsopercularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2441356	0.1153463	0.0464100
Weighted median	23	-0.1688131	0.0608703	0.0055487
Inverse variance weighted	23	-0.1070807	0.0457526	0.0192617
Simple mode	23	-0.1302575	0.1077265	0.2394397
Weighted mode	23	-0.1948731	0.0862157	0.0340402

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.27746	21	0.1324564
Inverse variance weighted	30.52118	22	0.1063374

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0084153	0.0065192	0.2107877

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011551	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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