Two sample MR report

Telomere_length against aparc-Desikan rh area parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0791272	0.0994068	0.4349420
Weighted median	23	-0.0322567	0.0554018	0.5604107
Inverse variance weighted	23	-0.0201918	0.0388457	0.6032066
Simple mode	23	-0.0267240	0.0818656	0.7471783
Weighted mode	23	-0.0301190	0.0561274	0.5969168

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.27528	21	0.6315232
Inverse variance weighted	19.45342	22	0.6171877

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0060981	0.0056182	0.2900382

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005977	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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