Two sample MR report

Telomere_length against aparc-Desikan rh area paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0270888	0.1142499	0.8148757
Weighted median	23	0.0012846	0.0602476	0.9829885
Inverse variance weighted	23	0.0050915	0.0436650	0.9071744
Simple mode	23	0.0619249	0.1106458	0.5813604
Weighted mode	23	0.0343242	0.0739909	0.6472781

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.74013	21	0.1476765
Inverse variance weighted	27.79793	22	0.1824750

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013506	0.0064571	0.8363321

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008429	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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