Two sample MR report

Telomere_length against aparc-Desikan rh area middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0751387	0.0994044	0.4581119
Weighted median	23	-0.0183790	0.0588535	0.7548245
Inverse variance weighted	23	-0.0227622	0.0388451	0.5578927
Simple mode	23	-0.0321450	0.1102283	0.7733076
Weighted mode	23	-0.0108139	0.0864889	0.9016332

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.36398	21	0.6888205
Inverse variance weighted	17.69164	22	0.7241065

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032159	0.0056181	0.5731165

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005465	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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