Two sample MR report

Telomere_length against aparc-Desikan rh area medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0217730	0.1342141	0.8726786
Weighted median	23	-0.0278034	0.0647470	0.6676208
Inverse variance weighted	23	-0.0557852	0.0517205	0.2807702
Simple mode	23	0.0598659	0.1279736	0.6445294
Weighted mode	23	0.0161737	0.0898967	0.8588665

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.28343	21	0.0119373
Inverse variance weighted	39.00192	22	0.0141048

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004762	0.0075854	0.5369108

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012442	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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