Two sample MR report

Telomere_length against aparc-Desikan rh area lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0905737	0.1141507	0.4363856
Weighted median	23	0.0729144	0.0586493	0.2137846
Inverse variance weighted	23	-0.0012102	0.0443262	0.9782183
Simple mode	23	0.1040318	0.1272139	0.4222574
Weighted mode	23	0.1357202	0.0899139	0.1454141

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.69317	21	0.1490699
Inverse variance weighted	28.64702	22	0.1552170

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005487	0.0064516	0.4046506

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008681	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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