Two sample MR report

Telomere_length against aparc-Desikan rh area lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0715530	0.1107621	0.5252726
Weighted median	23	-0.0231482	0.0570343	0.6848416
Inverse variance weighted	23	-0.0035985	0.0428315	0.9330439
Simple mode	23	-0.0522837	0.0896380	0.5656395
Weighted mode	23	-0.0212861	0.0659761	0.7500187

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.07218	21	0.2037100
Inverse variance weighted	26.74674	22	0.2210039

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046143	0.00626	0.4692145

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008107	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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