Two sample MR report

Telomere_length against aparc-Desikan rh area lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0234218	0.1202894	0.8474897
Weighted median	23	0.0139068	0.0589003	0.8133494
Inverse variance weighted	23	0.0266122	0.0461477	0.5641594
Simple mode	23	-0.0216470	0.0908318	0.8138391
Weighted mode	23	0.0221401	0.0646084	0.7350902

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.7503	21	0.0779152
Inverse variance weighted	31.0493	22	0.0951111

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030721	0.0067985	0.6559904

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000955	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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