Two sample MR report

Telomere_length against aparc-Desikan rh area isthmuscingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0521661	0.1375123	0.7082326
Weighted median	23	0.0158601	0.0579515	0.7843320
Inverse variance weighted	23	0.0043291	0.0527487	0.9345907
Simple mode	23	0.0013612	0.0998643	0.9892478
Weighted mode	23	0.0364405	0.0577170	0.5343075

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.18627	21	0.0070583
Inverse variance weighted	40.56748	22	0.0092736

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034688	0.0077719	0.6599303

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012296	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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