Two sample MR report

Telomere_length against aparc-Desikan rh area insula

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1330329	0.1181658	0.2729458
Weighted median	23	-0.0446763	0.0567370	0.4310309
Inverse variance weighted	23	-0.0317649	0.0460362	0.4901952
Simple mode	23	-0.1381952	0.0997503	0.1798134
Weighted mode	23	-0.0900958	0.0645925	0.1769907

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.67457	21	0.0987253
Inverse variance weighted	30.89944	22	0.0981917

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0062178	0.0066784	0.3624192

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009566	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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