Two sample MR report

Telomere_length against aparc-Desikan rh area inferiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0033739	0.0994050	0.9732445
Weighted median	23	0.0045867	0.0583862	0.9373845
Inverse variance weighted	23	-0.0159647	0.0388453	0.6810868
Simple mode	23	0.0420155	0.0995273	0.6770119
Weighted mode	23	-0.0013986	0.0752732	0.9853430

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.25275	21	0.5689304
Inverse variance weighted	19.27168	22	0.6284974

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007731	0.0056182	0.8918656

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005891	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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