Two sample MR report

Telomere_length against aparc-Desikan rh area inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0474845	0.1230894	0.7035457
Weighted median	23	-0.0317477	0.0562768	0.5726620
Inverse variance weighted	23	-0.0352997	0.0475875	0.4582175
Simple mode	23	0.0617304	0.0953880	0.5242304
Weighted mode	23	-0.0093754	0.0545081	0.8650106

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.19805	21	0.0559011
Inverse variance weighted	33.01656	22	0.0616412

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0050829	0.0069567	0.4730676

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010254	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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