Two sample MR report

Telomere_length against aparc-Desikan rh area fusiform

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1447767	0.0994052	0.1600637
Weighted median	23	-0.0318849	0.0607783	0.5998543
Inverse variance weighted	23	0.0006015	0.0388453	0.9876465
Simple mode	23	-0.0151089	0.1015846	0.8831200
Weighted mode	23	-0.0119361	0.0696634	0.8655232

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.51648	21	0.5520448
Inverse variance weighted	21.99921	22	0.4599356

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0088524	0.0056182	0.1300484

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006666	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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