Two sample MR report

Telomere_length against aparc-Desikan rh area frontalpole

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1642708	0.1340462	0.2339617
Weighted median	23	0.0649742	0.0563776	0.2491224
Inverse variance weighted	23	-0.0156266	0.0537054	0.7710746
Simple mode	23	0.0334847	0.0992914	0.7391351
Weighted mode	23	0.0422431	0.0580167	0.4742195

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.18550	21	0.0122584
Inverse variance weighted	42.05082	22	0.0061629

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0110456	0.007576	0.1596383

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012791	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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