Two sample MR report

Telomere_length against aparc-Desikan rh area entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0642001	0.1074779	0.5566717
Weighted median	23	-0.0267299	0.0572533	0.6405917
Inverse variance weighted	23	-0.0027440	0.0414790	0.9472545
Simple mode	23	0.0736427	0.0953794	0.4482687
Weighted mode	23	-0.0323749	0.0734081	0.6634976

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.54891	21	0.2672292
Inverse variance weighted	25.08417	22	0.2930666

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041104	0.0060744	0.5060018

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007602	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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