Two sample MR report

Telomere_length against aparc-Desikan rh area cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0810607	0.1285436	0.5350994
Weighted median	23	0.0360688	0.0656425	0.5826811
Inverse variance weighted	23	0.0154746	0.0494351	0.7542583
Simple mode	23	-0.0861002	0.1314155	0.5191473
Weighted mode	23	0.1360396	0.1411123	0.3454982

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.11829	21	0.0274026
Inverse variance weighted	35.63210	22	0.0332381

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004027	0.0072651	0.5852286

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010845	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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