Two sample MR report

Telomere_length against aparc-Desikan rh area caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1575459	0.1078826	0.1589950
Weighted median	23	-0.0843992	0.0561374	0.1327258
Inverse variance weighted	23	-0.0664049	0.0420064	0.1139170
Simple mode	23	-0.0715117	0.0891678	0.4311367
Weighted mode	23	-0.0748933	0.0629658	0.2469506

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.73444	21	0.2588489
Inverse variance weighted	25.72658	22	0.2636062

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005596	0.0060973	0.369148

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008681	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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