Two sample MR report

Telomere_length against aparc-Desikan rh area caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0507931	0.1085027	0.6445154
Weighted median	23	-0.0526608	0.0565131	0.3514224
Inverse variance weighted	23	-0.0244561	0.0419816	0.5602012
Simple mode	23	0.0136650	0.0926724	0.8841161
Weighted mode	23	-0.0544301	0.0654095	0.4142696

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.01841	21	0.2463676
Inverse variance weighted	25.69470	22	0.2650208

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046203	0.0061323	0.4595544

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007906	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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