Two sample MR report

Telomere_length against aparc-Desikan rh area bankssts

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0750415	0.1144044	0.5189907
Weighted median	23	0.0036479	0.0614824	0.9526873
Inverse variance weighted	23	0.0196912	0.0445121	0.6582148
Simple mode	23	0.2317893	0.1102316	0.0471532
Weighted mode	23	-0.0171587	0.0717457	0.8131956

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.81527	21	0.1454688
Inverse variance weighted	28.88714	22	0.1481114

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0058165	0.0064658	0.378544

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008831	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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