Two sample MR report

Telomere_length against aparc-Desikan rh area TotalSurface

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0249656	0.1183613	0.8349772
Weighted median	23	-0.0356223	0.0647046	0.5819508
Inverse variance weighted	23	-0.0536913	0.0452637	0.2355476
Simple mode	23	0.0582669	0.1239686	0.6429710
Weighted mode	23	0.0190277	0.0955047	0.8439102

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.77258	21	0.0966542
Inverse variance weighted	29.87113	22	0.1216304

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017638	0.0066895	0.7946128

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000963	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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