Two sample MR report

Telomere_length against aparc-Desikan lh volume transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2647088	0.1029673	0.0178175
Weighted median	23	-0.1352816	0.0574827	0.0186011
Inverse variance weighted	23	-0.1039643	0.0419180	0.0131314
Simple mode	23	-0.1831722	0.0915614	0.0579333
Weighted mode	23	-0.1674567	0.0633165	0.0147984

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.53256	21	0.3693981
Inverse variance weighted	25.61881	22	0.2684077

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0098697	0.0058195	0.1046665

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009934	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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