Two sample MR report

Telomere_length against aparc-Desikan lh volume supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0839162	0.0994053	0.4080817
Weighted median	23	-0.0837873	0.0553777	0.1302757
Inverse variance weighted	23	-0.1071172	0.0388451	0.0058237
Simple mode	23	-0.0168756	0.0914824	0.8553361
Weighted mode	23	-0.0949770	0.0573369	0.1118210

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.46896	21	0.7987070
Inverse variance weighted	15.53325	22	0.8383562

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014245	0.0056182	0.802302

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007011	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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