Two sample MR report

Telomere_length against aparc-Desikan lh volume superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0691199	0.0999981	0.4970027
Weighted median	23	-0.0586912	0.0554517	0.2898640
Inverse variance weighted	23	-0.0757939	0.0388454	0.0510368
Simple mode	23	-0.0271973	0.0939458	0.7749095
Weighted mode	23	-0.0798904	0.0622672	0.2128354

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.25094	21	0.4437138
Inverse variance weighted	21.25626	22	0.5049530

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004098	0.0056517	0.9428848

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007595	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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