Two sample MR report

Telomere_length against aparc-Desikan lh volume superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1508174	0.1006181	0.1487802
Weighted median	23	-0.0457591	0.0607436	0.4512604
Inverse variance weighted	23	-0.0554200	0.0393736	0.1592669
Simple mode	23	0.0232921	0.1282831	0.8575843
Weighted mode	23	-0.1870639	0.0864323	0.0415674

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.51606	21	0.4278411
Inverse variance weighted	22.60306	22	0.4244250

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0058575	0.0056868	0.3147205

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007466	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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