Two sample MR report

Telomere_length against aparc-Desikan lh volume superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1773031	0.1210226	0.1577219
Weighted median	23	-0.1882013	0.0580605	0.0011891
Inverse variance weighted	23	-0.1121335	0.0465806	0.0160710
Simple mode	23	-0.2062440	0.0904946	0.0327222
Weighted mode	23	-0.2120408	0.0732890	0.0084357

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.12799	21	0.0715541
Inverse variance weighted	31.63528	22	0.0838302

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040014	0.00684	0.5647758

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012111	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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