Two sample MR report

Telomere_length against aparc-Desikan lh volume rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1125428	0.1163293	0.3443296
Weighted median	23	-0.1651820	0.0617088	0.0074330
Inverse variance weighted	23	-0.1061986	0.0444173	0.0168057
Simple mode	23	-0.2355640	0.1264001	0.0757751
Weighted mode	23	-0.2146978	0.0916888	0.0286640

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.76049	21	0.1198713
Inverse variance weighted	28.76530	22	0.1516844

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003895	0.0065747	0.953315

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010981	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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