Two sample MR report

Telomere_length against aparc-Desikan lh volume rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0550390	0.1306974	0.6779481
Weighted median	23	-0.0524411	0.0627560	0.4033604
Inverse variance weighted	23	-0.0490954	0.0499023	0.3251984
Simple mode	23	-0.0696138	0.1145649	0.5496503
Weighted mode	23	-0.0253597	0.0841895	0.7660740

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.30316	21	0.0202110
Inverse variance weighted	36.30738	22	0.0281403

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003649	0.0073868	0.9610643

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011485	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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