Two sample MR report

Telomere_length against aparc-Desikan lh volume precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3071960	0.1303271	0.0282009
Weighted median	23	-0.1121489	0.0596278	0.0599969
Inverse variance weighted	23	-0.0410663	0.0552815	0.4575673
Simple mode	23	-0.1218474	0.1038444	0.2531971
Weighted mode	23	-0.1411629	0.0785970	0.0862368

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.09782	21	0.0213184
Inverse variance weighted	44.55731	22	0.0030189

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0163404	0.0073658	0.037683

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001384	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8