Two sample MR report

Telomere_length against aparc-Desikan lh volume precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2581980	0.1117048	0.0310492
Weighted median	23	-0.1570885	0.0596491	0.0084499
Inverse variance weighted	23	-0.1172799	0.0445145	0.0084225
Simple mode	23	-0.2397615	0.1072339	0.0358270
Weighted mode	23	-0.1942838	0.0721555	0.0132984

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.51938	21	0.1873333
Inverse variance weighted	28.89130	22	0.1479905

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086524	0.0063133	0.1850047

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011517	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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