Two sample MR report

Telomere_length against aparc-Desikan lh volume posteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1220261	0.1126513	0.2909922
Weighted median	23	-0.0120122	0.0569765	0.8330218
Inverse variance weighted	23	-0.0401520	0.0436434	0.3575727
Simple mode	23	0.0203356	0.0975172	0.8367312
Weighted mode	23	0.0237749	0.0770809	0.7606485

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.96891	21	0.1718846
Inverse variance weighted	27.76954	22	0.1834450

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050271	0.0063669	0.4386003

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008738	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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