Two sample MR report

Telomere_length against aparc-Desikan lh volume postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2659718	0.1140213	0.0296948
Weighted median	23	-0.1412789	0.0575208	0.0140440
Inverse variance weighted	23	-0.0921048	0.0462893	0.0466171
Simple mode	23	-0.1627679	0.1156083	0.1731272
Weighted mode	23	-0.1627679	0.0720864	0.0342080

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.63038	21	0.1509490
Inverse variance weighted	31.24111	22	0.0912863

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0106754	0.0064442	0.11247

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001117	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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