Two sample MR report

Telomere_length against aparc-Desikan lh volume pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1472742	0.1292140	0.2672162
Weighted median	23	-0.0590276	0.0613777	0.3361949
Inverse variance weighted	23	-0.0217607	0.0506242	0.6673069
Simple mode	23	-0.1381755	0.1175563	0.2523997
Weighted mode	23	-0.1501579	0.0887871	0.1049154

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.48400	21	0.0249673
Inverse variance weighted	37.36566	22	0.0215599

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0077065	0.0073029	0.3032912

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011417	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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