Two sample MR report

Telomere_length against aparc-Desikan lh volume parstriangularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1646303	0.0994050	0.1125574
Weighted median	23	-0.0275996	0.0538664	0.6083907
Inverse variance weighted	23	-0.0643279	0.0388450	0.0977189
Simple mode	23	-0.0099841	0.0982266	0.9199601
Weighted mode	23	-0.0436299	0.0681825	0.5288468

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.24102	21	0.7559597
Inverse variance weighted	17.44266	22	0.7384746

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061586	0.0056182	0.2854077

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006116	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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