Two sample MR report

Telomere_length against aparc-Desikan lh volume parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1442788	0.1513309	0.3512339
Weighted median	23	-0.0310147	0.0592174	0.6004573
Inverse variance weighted	23	0.0001586	0.0592375	0.9978644
Simple mode	23	0.1711286	0.1057928	0.1200019
Weighted mode	23	-0.1347247	0.0853048	0.1285311

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.66940	21	0.0005570
Inverse variance weighted	51.16116	22	0.0004077

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0088685	0.0085529	0.3115775

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015499	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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