Two sample MR report

Telomere_length against aparc-Desikan lh volume parsopercularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2466128	0.0994041	0.0216518
Weighted median	23	-0.0792400	0.0587989	0.1777723
Inverse variance weighted	23	-0.0495866	0.0406502	0.2225275
Simple mode	23	-0.0604702	0.1169273	0.6102046
Weighted mode	23	-0.1631512	0.0838056	0.0644406

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.45597	21	0.5559151
Inverse variance weighted	24.09263	22	0.3423926

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0120975	0.0056182	0.0430703

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007794	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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