Two sample MR report

Telomere_length against aparc-Desikan lh volume parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1222157	0.0994059	0.2324965
Weighted median	23	-0.0469332	0.0526712	0.3728968
Inverse variance weighted	23	-0.0474087	0.0388453	0.2222957
Simple mode	23	0.0476151	0.0903167	0.6033303
Weighted mode	23	-0.0673129	0.0618404	0.2881583

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.08378	21	0.8659737
Inverse variance weighted	14.75217	22	0.8726524

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045931	0.0056182	0.4227946

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004922	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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