Two sample MR report

Telomere_length against aparc-Desikan lh volume paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2233627	0.1310062	0.1029495
Weighted median	23	-0.1433101	0.0659868	0.0298708
Inverse variance weighted	23	-0.0598464	0.0521614	0.2512453
Simple mode	23	-0.2066176	0.1810297	0.2659976
Weighted mode	23	-0.2275389	0.0970232	0.0284444

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.47730	21	0.0193134
Inverse variance weighted	39.67111	22	0.0118085

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0100401	0.0074043	0.1895085

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001274	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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