Two sample MR report

Telomere_length against aparc-Desikan lh volume middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1469396	0.0994052	0.1542004
Weighted median	23	0.0210756	0.0578610	0.7156749
Inverse variance weighted	23	0.0264065	0.0392185	0.5007448
Simple mode	23	0.1040348	0.1060523	0.3372698
Weighted mode	23	0.0148899	0.0788273	0.8519086

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.83590	21	0.5956664
Inverse variance weighted	22.42491	22	0.4347847

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0106434	0.0056182	0.0720172

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006935	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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