Two sample MR report

Telomere_length against aparc-Desikan lh volume medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0874367	0.1451022	0.5532356
Weighted median	23	0.0234416	0.0585651	0.6889603
Inverse variance weighted	23	-0.0001213	0.0559620	0.9982703
Simple mode	23	-0.0421980	0.1089627	0.7022773
Weighted mode	23	0.0320119	0.0647011	0.6256709

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.74508	21	0.0018704
Inverse variance weighted	45.66073	22	0.0021861

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005376	0.0082008	0.5192335

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013835	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8