Two sample MR report

Telomere_length against aparc-Desikan lh volume lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1102446	0.0994062	0.2799563
Weighted median	23	0.0194040	0.0548312	0.7234245
Inverse variance weighted	23	-0.0179396	0.0388454	0.6442098
Simple mode	23	0.0171317	0.1020149	0.8681702
Weighted mode	23	0.0326971	0.0700181	0.6451059

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.65892	21	0.6704745
Inverse variance weighted	18.67655	22	0.6652076

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056675	0.0056182	0.3245655

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005724	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8