Two sample MR report

Telomere_length against aparc-Desikan lh volume lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0842548	0.1229301	0.5005959
Weighted median	23	-0.0053241	0.0655101	0.9352259
Inverse variance weighted	23	-0.0378602	0.0471208	0.4217023
Simple mode	23	-0.0013734	0.1116035	0.9902924
Weighted mode	23	-0.0051605	0.0773945	0.9474400

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.11446	21	0.0570061
Inverse variance weighted	32.37154	22	0.0712787

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028486	0.0069478	0.6859533

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010097	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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