Two sample MR report

Telomere_length against aparc-Desikan lh volume lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1196667	0.1506489	0.4358819
Weighted median	23	-0.1373815	0.0648056	0.0340145
Inverse variance weighted	23	-0.0200389	0.0582191	0.7306971
Simple mode	23	0.1186793	0.1381945	0.3997200
Weighted mode	23	-0.1562795	0.0897913	0.0957464

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.23375	21	0.0006390
Inverse variance weighted	49.41931	22	0.0007022

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061171	0.0085143	0.4803968

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015055	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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