Two sample MR report

Telomere_length against aparc-Desikan lh volume isthmuscingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1175918	0.1195382	0.3364529
Weighted median	23	0.0537482	0.0558611	0.3359615
Inverse variance weighted	23	0.0173809	0.0472450	0.7129566
Simple mode	23	-0.0175733	0.1008554	0.8632682
Weighted mode	23	0.0392917	0.0593273	0.5146661

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.36673	21	0.0848626
Inverse variance weighted	32.54254	22	0.0686053

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0082873	0.006756	0.2335293

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009921	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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