Two sample MR report

Telomere_length against aparc-Desikan lh volume insula

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2362217	0.0994052	0.0270752
Weighted median	23	-0.0869565	0.0557371	0.1187316
Inverse variance weighted	23	-0.0459536	0.0393212	0.2425360
Simple mode	23	-0.1425066	0.1066235	0.1950317
Weighted mode	23	-0.1205094	0.0647238	0.0760292

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.21863	21	0.6351296
Inverse variance weighted	22.54258	22	0.4279307

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0116824	0.0056181	0.0500205

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007255	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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