Two sample MR report

Telomere_length against aparc-Desikan lh volume inferiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1655166	0.1194344	0.1803389
Weighted median	23	-0.0569642	0.0626490	0.3632128
Inverse variance weighted	23	-0.0762892	0.0463098	0.0994824
Simple mode	23	-0.0711135	0.1227754	0.5683273
Weighted mode	23	-0.0237045	0.1027132	0.8196159

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.31875	21	0.0857675
Inverse variance weighted	31.26978	22	0.0907258

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054787	0.0067503	0.4261138

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010643	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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