Two sample MR report

Telomere_length against aparc-Desikan lh volume inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1591348	0.1141421	0.1778402
Weighted median	23	-0.0149636	0.0574629	0.7945517
Inverse variance weighted	23	0.0245094	0.0466405	0.5992383
Simple mode	23	0.0058374	0.1051917	0.9562465
Weighted mode	23	-0.0112531	0.0670936	0.8683337

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.68741	21	0.1492414
Inverse variance weighted	31.71542	22	0.0823789

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0112756	0.006451	0.0950908

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009731	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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