Two sample MR report

Telomere_length against aparc-Desikan lh volume fusiform

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0218020	0.1139539	0.8501104
Weighted median	23	-0.0692069	0.0551069	0.2091644
Inverse variance weighted	23	-0.0646234	0.0436788	0.1390028
Simple mode	23	-0.0670925	0.0878126	0.4529595
Weighted mode	23	-0.0559062	0.0610387	0.3696432

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.59663	21	0.1519665
Inverse variance weighted	27.81564	22	0.1818719

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026292	0.0064404	0.6872306

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009267	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8